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Bipolar Disorder

Easing Anxiety, Restoring Peace with Ketamine Therapy

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Rediscover Hope with Ketamine Therapy for Bipolar Disorder in the Greater Toronto Area

Living with bipolar disorder often means cycling between highs and lows that disrupt daily life. During depressive phases, motivation and energy can feel impossible to find. During manic or hypomanic phases, sleep, focus, and decision making may spin out of balance. These shifts can affect relationships, work, and your overall sense of stability.

For many, traditional treatments such as medications don’t always provide enough symptom relief, especially when depressive episodes are resistant to medication. At KetaMind Health, we offer intravenous (IV) ketamine therapy for those with bipolar depression. Our treatment is fast-acting, personalized, evidence-based, and designed to support a safe and effective healing process.

How Ketamine can Help in Bipolar Disorder

Bipolar depression is often the most challenging part of the disorder to treat. Traditional antidepressants may take weeks to work, and in some cases, may not work at all.
Research suggests that IV ketamine infusions can provide:

  • Rapid improvement in depressive symptoms, often noticeable within the first few treatments.
  • Support for treatment-resistant bipolar depression even when previous treatments and medications have not helped.
  • Reduced suicidal thoughts, with some people experiencing significant improvement within days.
  • Promotion of neuroplasticity, the brain’s ability to repair and strengthen neural connections disrupted by chronic mood instability.

By working through glutamate and NMDA receptor pathways (rather than serotonin alone), ketamine helps “reset” communication in key brain regions involved in mood regulation, such as the prefrontal cortex and hippocampus. This can promote healing and support recovery.

Benefits of Ketamine Infusion Therapy for Bipolar Disorder

Benefits of Ketamine Infusion Therapy for Bipolar Disorder

  • Improvement in depressive symptoms: Many patients report renewed energy, motivation, and emotional clarity during or after a series of infusions.
  • Stabilized mood: By supporting new neural pathways, ketamine can reduce the severity of the depressive phase of bipolar disorder.
  • Reduction in suicidal ideation: Ketamine has been shown to rapidly decrease suicidal thoughts, which is especially important for those at higher risk during depressive episodes.
  • Greater resilience: Patients often describe feeling more connected with themselves, better able to process their emotions, and more optimistic about recovery.

What to Expect During Treatment?

  • At KetaMind Health near Toronto, every session is carefully designed around your comfort and safety:
  • Comprehensive Assessment: We begin by reviewing your medical history, psychiatric profile, and current medications to ensure IV ketamine is an appropriate and safe option.
  • Preparation: Once we determine that ketamine is a good option for you, you will meet with a therapist to help you prepare for the infusions, understand what to expect and learn how to set intentions to optimize your mindset.
  • IV Ketamine Infusions: Treatment usually involves a series of six infusions over 3 weeks. Each session lasts about 60 minutes, during which you may experience a dissociative state, which is often described as a dream-like or “out-of-body” sensation.
  • Continuous Monitoring: Throughout your infusion, our expert team (led by Dr. Darren Ezer, anesthesiologist and medical director) monitors your vital signs, including heart rate, blood pressure, oxygen, and ECG, using state-of-the-art equipment. We will adjust your treatment plan and dosage as needed to ensure that your experience is safe and effective.
  • Integration Support: After treatment, a therapist can help you process and integrate your experience, reinforcing positive change and supporting long-term healing.

Is IV Ketamine Right for Bipolar Disorder?

IV ketamine may be an option if you:

  • Experience treatment-resistant bipolar depression despite trying previous medications.
  • Struggle with severe depressive symptoms.
  • Want a safe, medically supervised therapy to complement your existing treatment plan.
  • Don’t have any of the contraindications for treatment, such as current mania, or uncontrolled heart or blood pressure issues.

It’s important to note: ketamine is typically used to target the depressive symptoms of bipolar disorder and is not used to treat acute mania. Our clinical team carefully evaluates each patient to ensure ketamine therapy is safe, appropriate, and part of a holistic care plan.

Your Next Step

  • If traditional treatments haven’t provided the support you need, you’re not out of options. At KetaMind Health, we offer thoughtful, medically guided care for those living with the complexity of bipolar disorder especially when depression becomes difficult to manage.
  • Our experienced team will take the time to understand your history, your goals, and your concerns. We’ll walk you through each step of treatment and make sure that your care plan is tailored to your unique needs.

Ready to Explore IV Ketamine Therapy?

If you're ready to explore whether IV ketamine therapy is right for your bipolar depression, we invite you to reach out to us. You don’t have to navigate this alone.

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(416) 343-0074